In "The Seven Basic Plots" Booker classifies romance under Comedy - the plot where the protagonist works through increasingly complex and confusing stages of conflict before reaching a single (often simple) event that clarifies everything and leads to a happy ending.

If we are to take this definition, then some of the more complex espionage novels - I''m talking Le Carre and Len Deighton - would fall into this category. "Tinker, Tailor, Soldier, Spy" especially. There is also no doubt in my mind that "Hannibal" (the book not the film), falls into this category, despite its' goriness.

The more standard SF fare, along with the Flemoing-type spy novel, falls into the Overcoming the Monster story.